Jonathan L. Sessler报告会
Pyrrolic Receptors: From Sensors and Recognition to Self-Assembly
Jonathan L. Sessler
Department of Chemistry and Biochemistry, 105 E. 24th Street, Stop A5300, The Univ. of Texas at Austin, Austin, TX 78712-1224 USA
(e-mail: Sessler@mail.utexas.edu)
Pyrroles are found in several natural anion binding motifs. This inspired the development in our laboratory of calix[n]pyrroles as artificial, pyrrole-based anion binding agents. These synthetic compounds contain four or more pyrrole or pyrrole-like heterocyclic subunits within their non-conjugated frameworks. In this lecture calix[n]pyrroles will be discussed in the context of recent efforts to develop “tunable” systems that are 1) capable of binding and transporting selected substrates, including ion pairs, 2) acting as “molecular switches” and “logic gates” for electron transfer, as well as 3) serving as precursors for environmentally responsive, self-assembled materials. Other systems, including imidazolium-based macrocycles that act as electron deficient analogues of higher order calixpyrroles, will be presented as time permits.
Ongoing collaborations with the groups of Philip Gale, Bruce Moyer, Jan Jeppesen, Shunichi Fukuzumi, Chang-Hee Lee, Bielawski, Dongho Kim, Injae Shin, and Jong Seung Kim, as well as financial support from the National Institutes of Health, the National Science Foundation, and the U.S. Department of Energy is gratefully acknowledged.
Jonathan L. Sessler received his B.S. degree in 1977 from U.C. Berkeley and his Ph.D in 1982 from Stanford University (adviser: J. P. Collman), USA. After postdoctoral work with Jean-Marie Lehn and Iwao Tabushi, he commenced his independent career at The University of Texas at Austin in 1984, where he is now the Roland K. Pettit Centennial Chair in Chemistry. His research interests include expanded porphyrins, coordination chemistry, supramolecular chemistry, drug development, electron transfer, anion recognition, and non-covalent materials. Two of his compounds have advanced into human clinical trials.
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地点：玉泉校区教八(化学楼)218室
邀请单位：浙江大学化学系