Carsten Schmuck学术报告－《化学选论》系列之十八
来源：浙江大学化学系
发布时间：2011-03-31
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报告题目：Fascination supramolecular chemistry: from the recognition of biomolecules to switchable nanoassemblies
报告人：Prof. Dr. Carsten Schmuck
时间：2011-4-4（周一），上午9:30 地点：化学系教八-218
报告人简历：
Name Carsten Schmuck
Date of birth 20th of February 1968
Place of birth Oberhausen (Germany)
Nationality German
Address Institut für Organische Chemie
Universität Duisburg-Essen
Universitätsstraße 5
D-45141 Essen, Germany
Fon: 49(0)201 183 3097
E-Mail: carsten.schmuck@uni-due.de
Education and Carreer
Since June 2008 W3-Professor of Organic Chemistry (Chair) at the Institute of Organic Chemistry of the University Duisburg-Essen/Germany
March 2002 – May 2008 C3-Professor of Organic Chemistry at the Institute of Organic Chemistry of the University Würzburg/Germany
Sep. 1997 – March 2001 Assistant professor at the University of Cologne, Department of Organic Chemistry, Habilitation Thesis (2001): Guanidiniocarbonyl-pyrroles – a new binding motif for carboxylates
April 1995 – June 1997 Postdoctoral fellow at Columbia University, New York City, USA with Prof. Ronald Breslow
July 1992 – Nov. 1994 Doctoral research work at the Institute of Organic Chemistry of The Ruhr-University in Bochum (Germany) with Prof. Dr. W. R. Roth
Doctoral thesis: Radikalstabilisierungsenergie; Bestimmung von
Bildungsenthalpien und Diskussion der Strukturabhängigkeit
Oct. 1987 – May 1992 Study of Chemistry at the Ruhr-University Bochum (Diploma Degree in 1992)
Selected Awards and Fellowships
Firtz-Winter-Award of the Bavarian Academy of Science (2005)
Dozentenstipendium of the Fonds der Chemischen Industrie (since 2002)
Karl-Arnold-Award of the Academy of Science of the State of Nordrhein-Westfalen (2002)
Heisenberg-Fellowship of the German Science Foundation (2002)
Habilitation-Award of the Albertus-Magnus-University of Cologne (2001)
Fellowship of the Kurt-Alder Foundation Cologne (2001)
Award of the Hellmut-Bredereck-Foundation (2001)
Otto Röhm Memorial Award (2001)
German Science Foundation Habilitanden Fellowship (1999-2001)
SYNTHESIS–SYNLETT Journals Award (1999)
Liebig Fellowship of the Fonds der Chemischen Industrie (1997-1999)
Feodor Lynen Fellowship of the Alexander von Humboldt Foundation (1995-1997)
Doctoral Fellowship of the Studienstiftung des Dt. Volkes (1992-1994)
Student-Felowship of the Studienstiftung des Dt. Volkes (1987-1992)
Silver-medalist at the International Chemistry Olympiad in Vesprem/Hungary (1987)
Reseach Interest
Supramolecular chemistry, bioorganic chemistry, medicinal chemistry, self-assembling nanomaterials:
§ design and synthesis of host-guest systems for applications in aqueous solvents: e.g. peptide recognition, receptors for carbohydrates, anion sensing (organic synthesis, combinatorial chemistry, solid phase peptide synthesis)
§ quantitative thermodynamic studies of individual interactions within supramolecular host-guest systems using “knock-out” analogues (isothermal microcalorimetry, nmr, UV/Vis and fluorescence spectroscopy); solvent effects on noncovalent interactions
§ peptides and proteins with non-natural amino acids;
§ development of enzyme inhibitors as new potential drug candidates agains infectious diseases (enzyme assays, kinetic studies, synthesis of labeled inhibitors, microbiological testing); self-assembling zwitterions as a new class of vesicle formers
§ self-assembling zwitterions, switchable nanostructures and supramolecular polymers (atomic force microscopy, transmission electron microscopy, light scattering, small angle neutron scattering)
Selected Publications
1. Wich, P. R., Schmuck*, C. Reversible and Non-Competitive Inhibition of β-Tryptase by Protein Surface Binding of Tetravalent Peptide Ligands Identified from a Combinatorial Split-Mix-Library. Angew. Chem. Int. Ed. 2010, 122, 4207–4210; DOI: 10.1002/anie.200907221.
2. Lindgren, N. J. V., Geiger, L., Razkin, J., Schmuck*, C., Baltzer*, Lars. Downsizing Enzymatic Function by Chemical Methods – Arginine Mimics with Low pKa Values Increase Rates of Hydrolysis of RNA Model Compounds. Angew. Chem. Int. Ed. 2009, 48, 6722-6725; DOI: 10.1002/anie.200900595.
3. Schmuck*, C., Rehm, Th., Klein, K., Gröhn, F. Formation of Vesicular Structures via the Self-Assembly of a Flexible Bis-Zwitterion in DMSO. Angew. Chem. Int. Ed. 2007, 46, 1693-1697. DOI: 10.1002/anie.200603629
4. Schmuck*, C., Wich, P. Sequence dependent stereoselectivity in the binding of tetrapeptides in water by flexible artificial receptors. Angew. Chem. 2006, 118, 7383-4387; Angew. Chem. Int. Ed. 2006, 45, 4277-4281.
5. Schmuck,*C., Rehm, Th., Klein, K., Gröhn, F., Reinhold, F. Self-Assembly of a Flexible Bis-Zwitterion in Polar Solution: Formation of Discrete Nanometer-Sized Cyclic Dimers. J. Am. Chem. Soc. 2006, 128, 1430-1431.
6. Schmuck*, C., Jeil, M., Scheiber, J., Baumann, K. Charge Interactions do the Job: A Combined Statistical and Combinatorial Approach to Find Artificial Receptors for Tetrapeptide Binding in Water. Angew. Chem. Int. Ed. 2005, 44, 7208-7212.
7. Schmuck*, C., Geiger, L. Efficient complexation of N-acetyl-amino acid carboxylates in water by an artificial receptor: unexpected cooperativity in the binding of glutamate but not aspartate. J. Am. Chem. Soc. 2005, 127, 10486 - 10487.
8. Schmuck*, C., Schwegmann, M. A molecular flytrap for the selective binding of citrate and other tris-carboxylates in water. J. Am. Chem. Soc. 2005, 127, 3373 - 3379.
9. Schmuck*, C., Geiger, L. Dipeptide Binding in Water by a De-novo Designed Guanidiniocarbonylpyrrole Receptor. J. Am. Chem. Soc. 2004, 126, 8898-8899.
10. Schmuck*, C., Wienand, W. Highly Stable Self-Assembly in Water: Ion Pair Driven Dimerization of a Guanidiniocarbonyl Pyrrole Carboxylate Zwitterion”, J. Am. Chem. Soc. 2003, 125, 452-459
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