Jovica D Badjic 学术报告－《化学选论》系列之十六

Gated Molecular Encapsulation and Reactivity

Jovica D Badjic

Associate Professor

Department of Chemistry

The Ohio State University

Columbus, OH 43228 USA

The encapsulation of small compounds inside hosts allows for controlling their local

environment and properties. The stabilization of reactive intermediates, the promotion of chemical reactions, and the modulation of conformational dynamics have thus been investigated in confined spaces. The incorporation of dynamic elements of design into covalent or selfassembled hosts has been recognized as mandatory for controlling constrictive binding – the activation energy needed for a guest to enter the host. Interestingly, high constrictive binding is critical for increasing the lifetime of encapsulation-based complexes but its effect on promoting chemical reactions is still unknown. The relationship can be addressed by examining the interdependence between: the host’s conformational dynamics, the encapsulation kinetics and the rates of chemical reactions occurring in confined spaces. Accordingly, our research program has been focused on understanding working mechanisms of basket-like hosts capable to fold and control the kinetic stability of incarcerated guests (see Figure). The lecture will focus on presenting our recent efforts toward examining the reactivity in gated environments.

Biosketch

Jovica Badjic received his diploma in Chemistry (1994) from University of Belgrade (Serbia). He obtained Ph.D. in Organic Chemistry (2001) from Iowa State University. From 2001 to 2004 he was a postdoctoral research fellow in the group of J Fraser Stoddart at UCLA where he was awarded Chancellor's award for outstanding research accomplishments in postdoctoral work. He joined the faculty at the Ohio State University in 2004 and was promoted to associate professor in 2010.

1. X. Bao, S. Rieth, S. Stojanovic, C. M. Hadad, J. D. Badjić, Molecular Recognition of a Transition State. Angew. Chem. Int. Ed. 2010, 49, 4816-4819.

http://www3.interscience.wiley.com/journal/123478068/abstract

2. S. Rieth, X. Bao, B-Y. Wang, C. M. Hadad, J. D. Badjić, Gated Molecular Recognition and Dynami Discrimination of Guests. J. Am. Chem. Soc. 2010, 132, 773-776.

http://pubs.acs.org/doi/abs/10.1021/ja908436c

3. B-Y. Wang, S. Rieth, J. D. Badjić, Tuning the Rate of Molecular Translocation. J. Am. Chem. Soc. 2009, 131, 7250-7252.

http://pubs.acs.org/doi/abs/10.1021/ja9023868

4. B-Y. Wang, X. Bao, Z. Yan, V. Maslak, C. M. Hadad, J. D. Badjić, A 3-fold "Butterfly Valve" in Command of the Encapsulation's Kinetic Stability. Molecular Baskets at Work. J. Am. Chem. Soc. 2008, 130, 15127-15133.

http://pubs.acs.org/doi/abs/10.1021/ja8041977

5. V. Maslak, Z. Yan, S. Xia, J. Gallucci, C. M. Hadad, J. D. Badjić, Design, synthesis, and conformational dynamics of a gated molecular basket, J. Am Chem. Soc. 2006, 128, 5887-5894.

http://pubs.acs.org/doi/abs/10.1021/ja060534l

6. J. D. Badjić, V. Balzani, A. Credi, S. Silvi, J. F. Stoddart. A molecular elevator, Science 2004, 303, 1845-1849.

http://www.sciencemag.org/cgi/content/abstract/303/5665/1845

7. N. M. Milović, J. D. Badjić, N. M. Kostić, Conjugate of Palladium(II) Complex and β-Cyclodextrin Acts as a Biomimetic Peptidase. J. Am. Chem. Soc. 2004, 126, 696-697.

http://pubs.acs.org/doi/abs/10.1021/ja038404p

 时间：2011年3月26日下午3点  地点：教八-218    欢迎参加！